Explore Prolia in-depth

Last Updated on Mon, 1 January 2024 | Medicines Information

Prolia is a widely-used medication that has been used in healthcare for many years. It's a key component in treating certain conditions. This drug, also known scientifically by the name Denosumab is sold under the tradename 'Prolia. It is a medication that has been prescribed by many health authorities around the world. This makes it an option trusted by physicians. The purpose of this article is to give a complete understanding of Prolia. It will highlight its benefits, possible side effects, opinions from experts, and how you can get started using the drug.

What is Prolia

Prolia, as previously stated, is the trade name of the drug Denosumab. This monoclonal anti-RANK Ligand antibody is designed to block the function and survival of osteoclasts (cells that destroy bone). Prolia reduces the breakdown of bone by inhibiting this particular protein.

Prolia: Uses and Benefits

Prolia has been shown to be effective in treating osteoporosis among postmenopausal woman who have a high fracture risk. It is used to treat:

Treatment of bone loss among men who have prostate cancer and are undergoing hormone therapy.
Treatment of bone loss among women receiving breast cancer treatment.

Prolia's effectiveness in treating these conditions has been validated by studies published in The Lancet and the New England Journal of Medicine.

Prolia: Benefits and Uses

Prolia has been shown to have several positive effects in clinical studies , including:

Postmenopausal osteoporotic women have a significant reduction in their risk of hip, spinal and non-spinal fractures.
Treatment for men who are undergoing hormonal ablation therapy to treat prostate cancer.
Benefits for solid tumour patients who have bone metastases.

There are many clinical studies and Research papers that support these benefits, including those in The Lancet Oncology and The Journal of Bone and Mineral Research.

Prolia Side Effects

Prolia, like all other medications can have unwanted side effects. The most common side effects include low back pain, muscle and skeletal pain, urinary infections, high cholesterol, and pain in the extremities. Other side effects can be more severe, such as hypocalcemia, or low calcium in the blood. They may also include jaw problems and unusual thigh fractures. Clinical studies in the Journal of Clinical Endocrinology & Metabolism and Bone have referred to these side effects.

Prolia: Experts' Opinions

Prolia is generally regarded by healthcare professionals as an effective medication that can benefit certain populations. A review in Therapeutic Advances in musculoskeletal disease found that experts believed Prolia was an effective osteoporosis treatment because it reduced fractures and increased bone mineral density. They also recommend monitoring potential side effects in particular for patients who have risk factors.

Prolia: How to Get Started

A healthcare professional administers Prolia as a single subcutaneous injection every six months. It's important to discuss your health history with your doctor before starting Prolia. This includes any existing conditions and medications that you are currently taking. During Prolia, it's important to keep up a healthy intake of vitamin D and calcium. It's also important to maintain good oral health and have regular dental checks since Prolia may cause jawbone issues.

Make sure you're not allergic to Prolia or Denosumab.
Tell your doctor if you're pregnant or planning to get pregnant.
Talk to your doctor about other supplements, vitamins or medications you may be taking.

Possible Side Effects To Note

Some people may also experience severe side effects, such as inflammation in the inner heart lining or skin infection. Prolia should be avoided by pregnant women as it can harm an unborn child. Prolia should not be taken by individuals who have low calcium levels in their blood.

Prolia (also known as Denosumab) has proved its value in medicine, especially in treating osteoporosis, and the bone loss that is associated with some cancers. Numerous clinical studies have shown that it has a number of benefits including reducing fracture risk and increasing bone mineral density. Like all medicines, Prolia can have side effects which must be closely monitored. Before starting Prolia, or any other medication, it is important to have a full discussion with your healthcare provider.